According to Brandon May of MD Magazine, the investigators of this study in JAMA Psychiatry enrolled 2046 community-dwelling adults from the Baltimore Longitudinal Study of Aging with an average age of 62.56 years at baseline. Participants with no cognitive impairment at the first study assessment were followed from 1980–2016. During this time, participants completed the 240-item Revised NEO Personality Inventory (NEO-PI-R) self-reported questionnaire for assessment of agreeableness, conscientiousness, extraversion, neuroticism and openness, among other personality facets.
“We did not find change in personality in the preclinical phase of Alzheimer’s disease,” lead investigator Antonio Terracciano, PhD, a guest researcher at the National Institute on Aging at the National Institutes of Health and associate professor, Department of Geriatrics, Florida State University College of Medicine in Tallahassee, Fla., told MD Magazine. “We examined data that spanned up to 36 years, and we did not see particular patterns of personality change in the people who later developed Alzheimer’s disease.”
To read more on other identifying factors of dementia and Alzheimer's, vist MD Magazine.