Dementia is a rising tidal wave of devastation for families and society. Age is the biggest risk factor. Alzheimer's disease, which is the leading cause of dementia, is the sixth-leading cause of death in the United States, and more than 5 million Americans are currently living with Alzheimer's. That figure is expected to triple by 2050, according to Science Daily.
The discovery is described in Alzheimer's & Dementia: The Journal of the Alzheimer's Association. The study analyzed small molecules called metabolites in blood samples drawn from 22,623 individuals, including 995 who went on to develop dementia. The participants were enrolled in eight research cohorts in five countries.
Researchers found that higher blood concentrations of molecules called branched-chain amino acids were associated with lower risk of future dementia. Another molecule, creatinine, and two very low-density lipoprotein (VLDL)-specific lipoprotein lipid subclasses also were associated with lower risk of dementia.
One high-density lipoprotein (HDL) and one VLDL lipoprotein subclass were associated with increased dementia risk.
These findings will broaden the search for drug targets in dementia caused by Alzheimer's disease, vascular disease and other subtypes, said Dr. Seshadri, professor of neurology at UT Health San Antonio. Formerly of Boston University, Dr. Seshadri is a senior investigator in the long-running Framingham Heart Study and leads the neurology working group within several international consortia.
Read more about this new discovery at Science Daily.