Experimental Approach to Wound Care May Improve Treatments

It may be possible to speed the healing process of diabetic wounds, bed sore, chronic ulcers, and other wounds with a “promising new approach” to treatment, according to researchers at Loyola University Health System.

In the February 2011 issue of the journal Expert Reviews in Dermatology, researchers said that suppressing certain immune cells called “neutrophils and natural killer T (NKT) cells” could expedite the skin healing process. These white blood cells act to kill bacteria and other germs that can infect wounds. NKT cells also recruit other white blood cells to the site of injury. But in some cases, these NKT cells can do more harm than good, researchers wrote.

Neutrophils can be beneficial to wound healing by gobbling up harmful bacteria and debris such as dead cells, according to the researchers. But neutrophils also can do harm—by producing enzymes that digest healthy surrounding tissue, leading to excessive scar tissue and slower healing.

“It’s a balancing act,” researchers wrote. “You need neutrophils but not too many of them.”

NKT cells respond to wound injuries by producing proteins called cytokines and chemokines that attract neutrophils and other white blood cells to the wound. A previous study at Loyola demonstrated that the presence of activated NKT cells slows down the healing process, while the absence of these cells leads to faster wound closure.

Researchers wrote that since neutrophils and NKT cells are among the earliest immune system responders to injury, “they serve as ideal targets for modulation of the wound-repair process.” For example, in experimental models, treatment with antibodies against surface molecules on neutrophils or NKT cells can inactivate the cells or prevent them from entering the wound.

Early treatment in high-risk patients using such therapeutic strategies may be able to “decrease the incidence and prevalence of chronic, non-healing wounds, reduce infectious complications and ameliorate associated health-care costs,” researchers wrote.

The study was supported by grants from the National Institutes of Health and the Dr. Ralph and Marian C. Falk Medical Research Trust.

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