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Stemming the threat of MDROs

October 10, 2014
by Tobi Schwartz-Cassell
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Methicillin-resistant Staphylococcus aureus

The dire statistics from the Centers for Disease Control and Prevention (CDC) on the soaring rates of antibiotic-resistant infection and resulting mortality haunt the long-term care (LTC) industry. Data show that antibiotic-resistant organisms account for roughly 2 million illnesses per year and 23,000 deaths; Clostridium difficile infections result in roughly 250,000 illnesses per year with 14,000 deaths. Although the total yearly cost to the U.S. economy of antibiotic-resistant organisms associated with urinary tract infections (UTIs), pneumonia, skin and soft tissue infections and C. diff have been difficult to calculate, estimates have ranged as high as $20 billion (for direct healthcare costs) and an additional $35 billion in lost productivity (2008 dollars).

And even though the simple act of hand-washing is the first line of defense against these insidious bugs, it’s going to take more than a burst of soap to mop up this mess.


“The ‘garden variety’ multidrug-resistant organisms (MDROs) such as Methicillin-resistant Staphylococcus aureus  (MRSA), Vancomycin-resistant enterococcus (VRE) and extended-spectrum beta-lactamases (ESBLs) continue to be identified in the LTC population and cause a variety of infections,” says Phenelle Segal, RN, CIC, president of Infection Control Consulting Services in Delray Beach, Fla. “Unfortunately however, we are seeing the ‘newest kid on the block’ that was originally identified in the hospital setting but has become more common in LTC facilities. The highly-resistant carbapenem-resistant enterobacteriaceae (CRE) group of organisms that was limited to Klebsiella pneumoniae but is now represented by many gram-negative organisms, has a high mortality rate, and there are no traditional antibiotics to combat illness from this group.”

David Condoluci, DO, chief patient safety and quality officer for Kennedy University Hospital in Stratford, NJ, adds: “In skilled nursing facilities, the antibiotic-resistant infections become a major problem because many residents are in closed quarters, plus they’re very debilitated. So if strict infection control procedures are not in place, these organisms can be transferred from one patient to another and can spread throughout the facility. And an infection such as C. diff can cause complications like sepsis.”

And if all that weren’t enough, “Hospitals are discharging patients at such an early stage of their illness that residents are being admitted to nursing homes with similar issues to the acute care facilities,” Segal says.


Beyond diligent hand-washing, Condoluci says, there is one blatant culprit: “Over the years, the use and abuse of antibiotics have caused these organisms to become resistant. In particular, the multiresistant gram-negative rods are sometimes immune to—not just some—but all of the traditional antibiotics we have available.”

The situation is critical, Segal explains, because “resistant organisms continue to outsmart the development of antibiotics to combat the infections resulting from them. Morbidity and mortality statistics tell the story of how dire a situation it is.”

But with stringent infection control, as outlined below, Condoluci says, “We will be able to control the emergence of these organisms. But in the end, organisms are very adaptable to their environment. So while we need to be diligent about how infections spread, we’re always going to see resistant organisms because the use of antibiotics is very pervasive in our society.”

And that pervasiveness is not limited to physicians prescribing antibiotics. Antibiotics are put in the feed of animals to help fatten them up and avoid some of the infections they might be predisposed to. “That, too, creates resistant bacteria. So I think MDROs are going to be around for the foreseeable future for sure, but that doesn’t mean we can’t be judicious and control how we use antibiotics and how we can prevent the emergence of these resistant organisms with good infection prevention practices and the use of antimicrobial agents,” Condoluci advises.


Condoluci outlines specific standards to be adhered to by not just LTC facilities, but by physicians, sub-acute facilities and hospitals: